this question will get a ton of answers.

Try a few of each and see which shoots the best out of your gun. Then it will take a few kills to decide which does the most/least damage. If damage isn't an issue than it will all be based on accuracy. Every gun shoots a little different, and every load shoots a little different out of each gun.

I don't think you will notice much differene between 50 and 55. Bullet design and powder will make the big difference. I don't shoot a 22-250 so I can't offer a starting point. Will you be using factory or re-loads?

 

flip a coin. Both will kill a coyote if put it in the right spot. When I'm looking at a bullet, I look more towards accuracy than velocity. You'll do well with either of the two choices you mentioned.

I personally am using the 50g Nosler BT, with 34.0g Varget, CCI 200, Win brass. It's on the slow side but it's still pretty fast. But I don't care how fast it is just so long as it's accurate. It also does a number on prairie dogs.

Flip a coin.

xdeano

 

save the pelt....use barnes bullets...

destroy things...hornady v-max

 

Bolth are fine. I Like the 50 grain Ballistic Tip in both 250 and 223 and buy them in bulk for loading, so that's what I use...

Pelts aren't worth anything anyway, so whatever you feels makes them dead fastest is the load/caliber to use...

 

i sighted in the other day with the winchesters USA 45gr JHP; very impressed with the groupings! i was origianally goign to get hornady's, but the 3 stores in bismarck/mandan didnt have them, so i opted for the "cheaper" ammo 40 rounds for $27, and was impressed!

 

If you are saving the hides the stay away from Hornady's 40 gr Vmax. They are very accurate but messy if you hit any bone at all. I hear very good things about the Barne's bullets for both hides and accuracy. JMO.

 

interesting. i have killed dozens of coyotes over the years with 22-250 and 220 swift rifles using the 40 gr. v-max. occasionally i did indeed make a mess with them, but the vast majority of the time they blew up inside and stayed there. i liked them very much, even registering a 583 yard kill with one. 40 grain nosler b-tips were a different story. thick base and tapered jacket made sure that most of the shrapnel exited the other side making a large crater to testify to the fact that something had gone through with a vengance. if i start shooting a high velocity .22 with light bullets again, i will resume use of the v-max 40. no matter what you use there will be periodic high damage impacts. i have had it happen with small case .17's. it usually happens when you strike were the shoulder joins the leg. nothing is ever 100%, you just play the odds and shoot as many yoters as you can!