I can tell you from personal experience that an 87gr pill moving at over 3000fps is more a powerhouse than you would imagine. It literally turned the heart and lungs of the first 2 deer I took with it to pulp. Downside: Very little to no blood trail. Upside: One DRT, the other went about 10 yards. No need for search and rescue with properly placed shots. I wouldn't hesitate to shoot out to 300 yards or even more, not that I've ever had to shoot that far. What it lacks in size it more than makes up for with the hydrostatic shock it generates.You didn't say anything about the guns that would be used. I will have to assume (always dangerous) that the 25-35 will be a lever gun with a tubular magazine, the 250 could be either bolt or lever, but with a box magazine. With these thoughts in mind, the 250 will have more range, but is still no powerhouse. You also didn't state how long the shots would be. If it is reasonable to expect a shot over 100 yards, the 250 is obviously the best choice. Whatever you use, good luck and enjoy yourself.